© 2022 Willow Biosciences Inc.
Our technology platform underpins everything we do
At its core, our FutureGrown™ platform technology is built on the age-old process of fermentation, perfected by years of combined experience from some of the best in the biotech industry. The platform uses biosynthesis to replicate the vast capabilities of nature by producing an individual molecule through precision fermentation to yield a pure, consistent & sustainable functional ingredient. Currently, very few companies have full technical and operational capabilities required to execute the end-to-end precision fermentation solution that Willow can deliver.
Key Technologies and Capabilities to Accelerate Strain Engineering and Process Development
At Willow Biosciences, we integrate powerful computational tools at every stage of the Design-Build-Test-Learn (DBTL) cycle, enabling smarter strain engineering and efficient lab operations. This results in rapid decision making, and faster delivery.
Employing the most advanced technologies in DNA sequencing and DNA synthesis ensures our strains and resulting data are generated quickly with precision and high quality.
Our Strain Engineering team represents the engine of our technology platform, integrating advanced genetic engineering tools to to engineer enzymes, pathways and entire genomes with precision and speed. The team is responsible for early discovery and characterization of genes and pathways required to produce target active ingredients resulting in the development of proof-of-concept strains. This forms the foundation from which the accelerated strain optimization begins, focused on diversity generation strategies to provide fuel so they can harness the power of recombination in successive rounds of engineering.
Our strain engineering cycles are rapid and iterative, building and screening through tens of thousands of enzyme variants and strains per week, generating very large and complex data sets that are skillfully mined to drive nature in the direction we need.
Willow Biosciences’ Chemical Development team works closely with the fermentation team to develop integrated, robust processes for isolation and purification of target ingredients , which is essential for development of a viable commercial synthetic biology processes.
Many biotechnology companies focus on strain engineering to drive efficiencies. Willow Biosciences has determined that an additional focus in chemical development leads to a faster, more economical overall process than strain engineering alone with only incremental investment.
The Willow Biosciences Manufacturing team works closely with our manufacturing partners to ensure a smooth and efficient transition of the developed lab process to large scale-that meets our targets for commercial production. No matter the production level, from 15,000L to 100,000L, Willow Biosciences’ manufacturing partners are experienced in meeting Good Manufacturing Practice (GMP) standards to produce cosmetic, food and nutrition, and pharmaceutical ingredients.
Willow’s Quality team ensure that products are manufactured in accordance with needed quality standards and are tested against pre-approved specifications using validated and/or verified methods (partners are routinely audited to ensure compliance to those standards). The expectation is that all product inputs used for manufacturing are sourced to meet high quality and that both materials and suppliers, are qualified and approved.
Willow Biosciences Inc. is committed to producing safe and effective products by
The Quality Control team develops, qualifies, and validates methods needed to support our development and manufacturing programs. They ensure methods are suited for their intended purposes during internal development, are transferred in accordance with regulatory requirements, to Contract Manufacturing and/or Contract Testing Organizations as required, support the stability testing program to determine shelf life of the products or intermediates. They ensure partners are monitoring their environments and process utilities to meet industry requirements, ensure and that raw materials are fully released prior to use in manufacturing, and that key performance metrics are met. They also support the stability testing programs to determine shelf life of the products or intermediates.
The Willow Biosciences Manufacturing team works closely with our manufacturing partners to ensure a smooth and efficient transition of the developed lab process to large-scale that meets our targets for commercial-level production. No matter the production level, from 15,000L to 100,000L, Willow Biosciences’ manufacturing partners are experienced in meeting Good Manufacturing Process (GMP) standards to produce cosmetic, food and nutrition, or pharmaceutical ingredients.
Focused on identifying and deploying additional genetic elements and solutions to further enhance production of our yeast strains and processes. This state-of-the-art R&D facility includes high-throughput molecular biology and screening technologies, high-end analytical instrumentation and fermentation capabilities along with systems to rapidly evaluate high volumes of data and results.